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Mouse and human goblet cells expressed Ramp1, receptor for the neuropeptide Calcitonin gene-related peptide (CGRP)
Nociceptors signal via the Calcitonin gene-related peptide (CGRP)-Ramp1 pathway to induce rapid goblet cell emptying and mucus secretion
Commensal microbes activated nociceptors to control homeostatic Calcitonin gene-related peptide (CGRP) release
In the absence of nociceptors or epithelial Ramp1, mice showed increased epithelial stress and susceptibility to colitis. Conversely, [Calcitonin gene-related peptide (CGRP)](brain://qW2T5TXMZUK…