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When the process of protein synthesis
and protein folding is out of balance, the ER responds by
inducing a transcriptional program, known as the
unfolded protein response (UPR),
Innate immunity and ER-signaling pathways
share common signaling modules
ER-stress boosts innate immunity and
inflammatory responses
ER-signaling components involved in innate
immunity
Regulation of ER-signaling pathways by
innate immune receptors
Martinon & Glimcher, 2011…