XXX - Saccharomyces boulardii + Vancomycin hydrochloride vs Saccharomyces boulardii + Metronidazole & Clostridioides difficile infection (CDI) (recurrent)

McFarland et al. 1994 JAMA 271(24): 1913–8 published the results of standard antibiotics (vancomycin or metronidazole) and S boulardii or placebo for 4 weeks to patients with Clostridium difficile—associated disease (CDD) from a double-blind, randomized, placebo-controlled, parallel-group intervention study with 124 subjects.
The authors' conclusion was: The combination of standard antibiotics and S boulardii was shown to be an effective and safe therapy for these patients with recurrent CDD; no benefit of S boulardii was demonstrated for those with an initial episode of CDD
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