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Roxadustat (EvrenzoTM) is the first drug from the class of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHI) to be approved for treating symptomatic anemia associated with chronic renal failure. It is used orally. The pivotal studies showed no additional benefit compared to conventional erythropoiesis-stimulating substances (ESAs). There are also safety concerns about the expensive drug.
AMB 2022-03 D…