Immune Checkpoint Inhibitors (ICIs) & Myocarditis

Among patients with myocarditis:

• Higher Troponin I (p=0.037) and creatine kinase-MD (CK-MB), (p=0.034) levels on presentation correlated with progression to severe myocarditis.


• Higher troponin I (p=0.016), CK (p=0.013), and CK-MB (p=0.034) levels were associated with increased mortality.


• The presence of advanced atrioventricular block on presentation (p=0.088) trended toward increased mortality.

Puzanov et al. 2021

Importance of Troponin Monitoring

Weekly troponin monitoring led to earlier hospitalization for potential myocarditis (p=0.022).
It was associated with decreased time to steroid initiation (p=0.053) and improved outcomes.
Puzanov et al. 2021

Routine trop…