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In the context of Ponatinib & Chronic myeloid leukemia / Chronic myelogenous leukemia (CML) (Ph+ CML), ponatinib is a third-generation TKI that is currently approved as per label when no other TKIs are indicated for the treatment of patients with Chronic myeloid leukemia / Chronic myelogenous leukemia (CML) (Ph+ CML) after failing treatment with second-generation TKIs or if presence of T315I mutation is discovered (1). Ponatinib is both FDA‑ and EMA‑approved for Chronic myel…