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Prednisone is not specifically "approved" as a primary, branded drug for ulcerative colitis by the FDA or EMA, but it is an accepted and guideline-endorsed standard therapy for the induction of remission in UC flares. Both agencies recognize systemic corticosteroids like prednisone as standard care in moderate to severe ulcerative colitis and include corticosteroids in treatment guidelines, but they do not list prednisone as a uniquely labeled UC drug with clinical trial-based label approval for this indication (1)
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