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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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AuthorsReferences (Sources)

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Cancer microbiome / Tumor microbiome & Colorectal cancer (CRC)

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Intracellular bacteria are present in various solid tumors, but their effects are not well understood. Research shows that Campylobacter is significantly enriched in primary colorectal cancer (CRC) lesions in patients with metastasis. The Campylobacter jejuni-derived cytolethal distending toxin (CDT) promotes CRC metastasis through JAK2-STAT3-MMP9 signaling, as observed in liver and pulmonary metastatic mouse models, and confirmed in infected human colonic tissue and CDT-treated tumoroids. The genotoxin CdtB is essential for the p…

References (Sources)

Co-occurrence of anaerobic bacteria in colorectal carcinomas
Warren et al. 2013 Microbiome 1: 16
Colorectal cancer mutational proﬁles correlate with deﬁned microbial communities in the tumor microenvironment
Burns et al. 2018 PLoS Genet 14: e1007376
Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia
Gurbatri et al. 2024 Nat Commun 15: 646
Fusobacterium nucleatum persistence and risk of recurrence after preoperative treatment in locally advanced rectal cancer
Serna et al. 2020 Ann Oncol 31: 1366-1375
Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy
Yu et al. 2017 Cell 170(3): 548-563
The cancer chemotherapeutic 5-fluorouracil is a potent Fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota
LaCourse et al. 2022 Cell Rep 41: 111625
The close interrelation between colorectal cancer, infection and microbiota
Massaut et al. 2019 Curr Opin Oncol 31: 362
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