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Changes in Gut Bacterial Taxa and Gene Family Abundance Were Distinct between Methotrexate (MTX) Responders and Non-responders. Methotrexate alters the human gut microbiota in cell culture, humanized mice, and patients.
Methotrexate (MTX) directly inhibits the growth of human gut bacterial isolates
Methotrexate (MTX), a first-line rheumatoid arthritis (RA) treatment, inhibits mammalian dihydrofolate reductase (DHFR), but whether it directly impacts gut bacteria is unclear.
There are significant links between the types and amounts of bacteria in the gut and how patients responded to [Methotrexate (MTX)](brain://VBR8E2XAMk-wA3CIeKXMmQ/Methotrexate…