Loading…
Please register to continue your trial period!
meRfi Microbiome provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Tumors in the omentum of microbe-rich mice grow unhindered due to immunosuppressive Tregs. Proteobacteria such as Escherichia coli (E. coli) in microbe-rich mice consume arginine, reducing serum arginine levels. This promotes Treg suppression and prevents tumor clearance.
In contrast, omental tumors in germ-free mice treated with neomycin or mice colonized with altered Schaedler flora are spontaneously eliminated by CD8+ T cells. These mice lack proteobacteria.
Meza-Perez et al. 2024…