Phage therapy

Phage therapy uses phages to treat bacterial infections and is becoming increasingly important because antimicrobial-resistant infections require alternative treatments (2).

Phage therapy faces several challenges:

• Isolating phages that infect a specific bacterial strain.


• Limited infectivity or killing ability of individual phages.


• The cost and technical complexity of producing well-characterized phage preparations.


• The emergence of bacterial resistance to phages (2).

Phage training - also called directed phage adaptation - is the deliberate adaptation of a phage to a specific bacterial target. It exploits the natural evolutionary capacity of phages to improve their ability to infect and kill bacteria.
Numerous laboratory studies have reported that phage training can:

• Improve bacterial killing.


• E…