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Intestinal mucus forms the first line of defense against bacterial invasion while providing nutrition to support microbial symbiosis.
Terminal sialylation of glycans on intestinal mucus by ST6GALNAC1 (ST6), the dominant sialyltransferase specifically expressed in goblet cells and induced by microbial pathogen-associated molecular patterns, is essential for mucus integrity and protecting against excessive bacterial proteolytic degradation.
[ST6](brai…