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The Rho-associated coiled-coil forming protein kinase (ROCK) has been implicated in the development of cardiac fibrosis and stiffening
Several studies have highlighted the potential of targeting ROCK to inhibit cardiovascular fibrosis and stiffening.
Inhibition of ROCK has been shown to suppress cardiac fibrosis, and genetic deletion of ROCK-1 in mice resulted in reduced fibrosis and cardiac dysfunction.
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