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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Mitogen-activated protein kinase kinase 3 (MKK3, MAP2K3)-MYC-PPI inhibitors

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We have discovered the first small molecule MKK3/MYC PPI inhibitors. For example, a quinoline derivative SGI-1027 disrupts the MKK3/MYC complex in cells and in vitro, inhibits MYC transcriptional activity, and suppresses the viability of Mammacarcinoma (TNBC) cells
West et al. 2023 Cancer Res 83 (7_Supplement): 441

see also:
Mitogen-activated protein kinase kinase 3 (MKK3, MAP2K3) & Mammacarcinoma (TNBC)
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References (Sources)

Targeting MKK3-MYC complex to reduce racial survival disparity in breast cancer [abstract]
West et al. 2023 Cancer Res 83 (7_Supplement): 441

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7/1/2026

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Mitogen-activated protein kinase kinase 3 (MKK3, MAP2K3)-MYC-PPI inhibitors

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