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TLR-1/2 is a heterodimer of TLR-1 and TLR-2 formed upon binding of a ligand to TLR-1 and TLR-2, respectively. It is localized on cell membranes.
The dimerization of TLR-1 and TLR-2 brings the cytoplasmic TIR (Toll IL-1 receptor) domain (closed rectangles) of the TLR chains into close proximity to initiate signaling.
see also:
B cells & TLR1 / TLR2 Heterodimer (TLR1/TLR2)
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