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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

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NCT02562014 - Glucose + Inulin-type fructans (ITF) / Inulin + Resistant starch (RS) (lean participants) vs Glucose + Inulin-type fructans (ITF) / Inulin + Resistant starch (RS) (overweight participants) & Adiposity / Obesity

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Background

Colonic fermentation of dietary fiber into short-chain fatty acids (SCFA) plays a role in influencing the secretion of appetite hormones in animals. However, in obese animals, the production of SCFA is excessive. This observation suggests that there might be a resistance to the effects of SCFA on appetite hormones in cases of obesity (1)

Study overview

It is a randomized, basic science, clinical trial studying Glucose + Inulin-type fructans (ITF) / Inulin + Resistant starch (RS) (lean participants) vs Glucose + Inulin-type fructans (ITF) / Inulin + Resistant starch (RS) (overweight participants) in pati…

References (Sources)

Acute increases in serum colonic short-chain fatty acids elicited by inulin do not increase GLP-1 or PYY responses but may reduce ghrelin in lean and overweight humans
Rahat-Rozenbloom et al. 2017 Eur J Clin Nutr 71(8): 953-958

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