NCT03127696 - Fecal Microbiota Transplantation (FMT) + Lifestyle intervention (LSI) vs Fecal Microbiota Transplantation (FMT) vs Lifestyle intervention (LSI) & Adiposity / obesity and Type 2 Diabetes (T2D)

Background

The effect of fecal microbiota transplantation (FMT) on the successful integration of microbiota in individuals with metabolic syndrome remains unclear.
Ng et al. 2022 Gut 71(4): 716-723

Study overview

It is a randomized placebo-controlled clinical trial to study Fecal Microbiota Transplantation (FMT) + Lifestyle intervention (LSI) or Fecal Microbiota Transplantation (FMT) or Lifestyle intervention (LSI) in 61 randomized patients with adiposity / obesity (BMI >=28 kg/m^2 and < 45 kg/m^2^) and Type 2 Diabetes (T2D)

Primary outcome measures

Proportion of subjects acquiring ≥20% of microbiota from lean donors at week 24

Results

At week 24, the proportions of subjects acquiring 20% or more of lean-associated microbiota were 100% in the FMT plus LSI group, 88.2% in the FMT alone gr…