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SPR741 is a structurally modified derivative of Polymyxin B. It acts as an antibiotic adjuvant by enhancing the effectiveness of other antibiotics. Its efficacy is particularly directed against gram-negative bacteria. SPR741 itself has minimal direct antibacterial activity but can permeabilize the outer membrane of gram-negative pathogens, thereby facilitating the penetration of antibiotics and their action. SPR741 has shown promising results in preclinical and early clinical studies in the combination treatment of multidrug-resistant infections caused by Acinetobacter baumannii or [Klebsiella pneumoniae](brai…