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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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CD284 (Toll-Like Receptor 4 (TLR-4)) & Dendritic Cells (DCs)

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CD284 (Toll-Like Receptor 4 (TLR-4)) engagement by Lipopolysaccharides (LPS) resulted in increased DC and self/tumor-specific Activation & Cytotoxic T cell (CTL) , leading to greater tumor regression.
Paulos et al. 2007 J. Clin. Invest. 117: 2197–2204

Lipopolysaccharides (LPS) causes differential DC migration and differential DC activation, depending on anatomical location
Turnbull et al., 2005 J Immunol.…

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Intestinal dendritic cell subsets: differential effects of systemic TLR-4 stimulation on migratory fate and activation in vivo
Turnbull et al., 2005 J Immunol. 174: 1374–84
Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling
Paulos et al. 2007 J. Clin. Invest. 117: 2197–2204

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CD284 (Toll-Like Receptor 4 (TLR-4)) & Dendritic Cells (DCs)

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