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A randomized double-blind trial to evaluate a probiotic drink (liquid yogurt containing L. casei DN-114 001 at 10H8 CFU/g) or placebo in patients who were undergoing pelvic radiotherapy for either cervical carcinoma (radiotherapy and weekly cisplatin) or endometrial adenocarcinoma (postoperative radiotherapy).
Primary outcome measures:
Reducing the incidence of diarrhea, defined by a Common Toxicity Criteria Grade of 2 or greater or the need for loperamide.
The authors concluded that nutritional intervention with the probiotic drink containing L. casei DN-114 001 does not reduce the incidence of radiation-induced diarrhea as defined by a Common Toxicity Criteria Grade 2 or greater. However, it significantly affected stool consistency as measured by the Bristol scale.
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