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4-Aminobutyric acid / GABA is the brain’s main inhibitory neurotransmitter, and current reviews describe a “GABAergic hypothesis” of depression in which impaired inhibitory signaling contributes to depressed mood, stress dysregulation, and altered emotional processing (; ).
Clinical imaging and biochemical studies summarized in recent reviews found altered GABA concentrations in patients with major depressive disorder, including findings from magnetic resonance spectroscopy, plasma, cerebrospinal fluid, and corti…