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A diet rich in fat, sugar, and Food additives leads to a decrease in microbiome diversity (dysbiosis), which leads to an increase in Enterobacteriaceae and Enterococcaceae. By that inflammatory type 1 immune cells (Th1 T cells, monocytes, macrophages, and neutrophils) are activated to produce cytokines such as IL-1 beta and TNF-alfa. The immune cells increase inflammation in the intestine. Moreover, the reduced microbiome diversity is responsible for an increased permeability through the opening of tight junctions