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The rationale for Probiotics (living agents) + Selective serotonin reuptake inhibitors (SSRIs) is biologically plausible because Selective serotonin reuptake inhibitors (SSRIs) are associated with gut microbiome changes. A review on serotonin reuptake inhibitors and the gut microbiome also notes that SSRIs can affect gut microbes and that probiotic replenishment may modulate treatment effects and side effects, although this mechanistic literature is not itself proof of clinical efficacy
Five studies met eligibility criteria and were analyzed for rep…