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Although it is clear that past and present exposure to commensals and pathogens profoundly affects human physiology, such disclosure is lacking in standard preclinical models such as laboratory mice .
Microbial products Such as Bile Acids Interact with Nuclear Receptors on Host Drug-metabolizing Enzyme Machinery, Thus Indirectly Influencing Drug Disposition and Pharmacokinetics
The Gut Microbiome Interacts Directly with Drugs to Break Them down into Metabolic Products
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