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As the only interferon, Interferon Type II (IFN Type II) / Interferon Gamma (IFN-g) binds to the Type II Interferon Receptor.
This is a special receptor complex (IFNGR) composed of CD119 / Interferon gamma receptor 1 (IFNGR1) and Interferon Gamma Receptor 2 (IFNGR2). It is expressed by activated T cells and NK cells and enhances antigen presentation and macrophage activation. Additionally, it promotes [Th1-mediated inflamma…