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The bacterial injectisome is a structurally conserved, syringe-shaped nanomachine that spans the Gram-negative envelope and forms a continuous channel for type III secretion of protein effectors.
The injectisome, and the host-modulating effectors it secretes, are essential for the pathogenesis of several Gram-negative bacterial species. In addition, it is a crucial virulence factor associated with the progression of many clinical and community-based infectious diseases.
Jenkins et…