RAR-related orphan receptor gamma/t (ROR-gamma/t) Isoform 2 (NR1F3)

Master regulator of T helper 17 cell differentiation
Ivanov et al. 2006 Cell 126: 1121-33

The transcription factor RAR-related orphan receptor gamma/t (ROR-gamma/t) Isoform 2 (NR1F3) is required for the differentiation of all IL-22 producing immune cell subsets (e.g., T helper 17 cell (Th17), Gamma Delta T Cells, and group 3 innate lymphoid cells (ILC3)) (Brooks II & Hooper 2020). The expression of RAR-related orphan receptor gamma/t (ROR-gamma/t) Isoform 2 (NR1F3) is regulated by NFIL3, which is controlled by the T cell-intrinsic circadian clock
Yu et al. 2013a Science 342: 727-730

It is expressed in immature CD4+ T helper cells / CD8+ T cells, too.

RAR-related orphan receptor gamma/t (ROR-gamma/t) Isoform 2 (NR1F3), encoded by rorc gene non-mutant, is preferentially expressed in RAR-related Orphan Receptor Gamma/T (ROR-gamma/t) Isoform 2 (NR1F3)t+ Foxp3+ Colonic Treg cells
Sefik et al. 2015 Science 349(6251): 993-997

RAR-related orphan receptor gamma/t (ROR-gamma/t) Isoform 2 (NR1F3)-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces
Satoh-Takayama et al. 2008 Immunity 29: 958