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RNA Polymerase (RNAP) mutations can also contribute to resistance to Beta-lactam antibiotics. These antibiotics block cell-wall production
According to the WHO, bacterial antimicrobial resistance (AMR) is a critical global public health challenge.
Early clinical successes have been achieved with glycomimetics and vaccines for the treatment and prevention of AMR-related infections.
Horizontal gene transfer is the primary mechanism for the spread of antibiotic resistance in bacteria
Antimicrobial resistant (AMR) bacterial infections represent an escalating global health crisis, expected to cause 10 million deaths annually by 2050. Due to antibiotic resistance, currently, 1.27 million people die from such infections each year.
The resistance of intestinal pathogens to Antibiotics (J01) varies significantly across different regions. This variation is influenced by local health practices and regulations concerning antibiotic use. Additionally, vaccines developed to protect against these pathogens may not be equally effective worldwide.
Deaths in the USA from Antimicrobial resistance (AMR) infections increased by 15% between 2019 and 2020 alone.
Antibiotic-resistant infections challenge treatment with conventional therapies, creating an urgent demand for new Antibiotics (J01)
The widespread administration of Antibiotics (J01) during the COVID-19 pandemic accelerated this trend by promoting the development of resistance in bacterial infections.
Hospitals see more Antibiotic resistance due to more patients and surgeries, leading to more antibiotic use.
The rapid rise of antibiotic resistance poses a serious threat to healthcare
It reduces the available therapeutics against multi-resistant pathogens, which often cause nosocomial infections. Short peptides, with fewer than 50 amino acids, offer promising possibilities as antimicrobial agents due to their large sequence space and nonspecific mechanisms of action
There are high resistance developments against gentamicin and vancomycin
Antibiotic resistance is clinically relevant and are abundant in the Proteobacteria phylum, suggesting that this phylum may be a reservoir for opportunistic pathogens
A study found that urban areas have higher rates of antibiotic resistance because Antibiotics (J01) are prescribed more often in cities with hospitals
Non-antibiotics may promote antibiotic resistance
see also:
Antibiotics (J01)
Antimicrobials / Antimicrobial activity
Antimicrobial resistance (AMR / AR)
Antimicrobial peptides (AMPs) & Antimicrobial resistance (AMR / AR)
Bacteremia / Bloodstream infections
Bacterial enteric infections
Opportunistic infections
Pathogenic Bacteria
RNA Polymerase
Vancomycin - resistant Enterococci strains (VRE)