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Ephrin receptors have pro-tumorigenic effects
The activation of EPH receptor A1with EphrinA1-fc in vitro led to an increase in Chemokine (C-X-C motif) ligand 12 (CXCL12) / Stromal cell-derived factor 1 expression. This increase promotes chemotaxis and facilitates the transition of Endothelial progenitor cells (EPCs) to hepatocellular carcinoma (HCC) cells. Additionally, it enhances the tube formation of EPCs. These proce…