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Elacestrant is FDA approved for the treatment of postmenopausal women and adult men with Breast Cancer / Mammacarcinoma (HR+) (ER+) (Her2-), ESR1-mutated advanced or metastatic breast cancer, following progression on at least one line of endocrine therapy. This makes it the first oral selective estrogen receptor degrader (SERD) approved for this indication, based on results from the EMERALD phase III trial demonstrating superior progression-free survival compared to standard endocrine therapies in ESR1-mutated cases.
Shah et al. 2024 J Clin Oncol…