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FDA approved on 25 March 2011 for unresectable or metastatic Melanoma (cutaneous), approved on 28 October 2015 for adjuvant treatment in cutaneous melanoma with pathologic regional lymph node involvement >1 mm after complete resection, including total lymphadenectomy.
EMA approved for advanced (unresectable or metastatic) Melanoma (cutaneous) in adults, since 2017, also approved for adolescents aged 12 (5)
Phase III studies with ipilimumab have demonstrated survival benefit in both previously treated and treatment-naïve patients with metasta…