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Staphylococcus aureus

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Function of Naphtho-γ-pyrones (NGPs) from the Fungus Aspergillus welwitschiae

Marine-derived compounds, such as Naphtho-γ-pyrones (NGPs) from the fungus Aspergillus welwitschiae, can inhibit important properties of Staphylococcus aureus. These include biofilm formation and the destruction of red blood cells. NGPs directly target toxins such as hemolysin (43).

How Effective Are Naphtho-γ-pyrones (NGPs) Against Staphylococcus aureus Infections?

Naphtho-γ-pyrones (NGPs) reduced the harmful effects by approximately 80%. When combined with the antibiotic [vancomycin](brain://api.thebrain.com/wzsofVOsh4ANI-lTZFb…

References (Sources)

Accessory Gene Regulator (agr) Allelic Variants in Cognate Staphylococcus aureus Strain Display Similar Phenotypes
Tan et al. 2022 Front Microbiol 13: 700894
Disarming Staphylococcus aureus: Review of Strategies Combating This Resilient Pathogen by Targeting Its Virulence
Touati et al. 2025 Pathogens 14: 386
Review
High-level production of violacein by the newly isolated Duganella violaceinigra str. NI28 and its impact on Staphylococcus aureus.
Choi et al. 2015 Sci Rep 5: 15598
Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides
Peschel et al. 1999 J Biol Chem 274: 8405-8410
Mitochondrial calcium uniporter affects neutrophil bactericidal activity during Staphylococcus aureus infection
Monteith et al. 2022b Infect Immun 90: e0055121
Polyketides from Marine-Derived Aspergillus Welwitschiae Inhibit Staphylococcus aureus Virulence Factors and Potentiate Vancomycin Antibacterial Activity in Vivo
Loges et al. 2020 Microb Pathog 143: 104066
Suppression of Staphylococcus aureus superantigen-independent interferon gamma response by a probiotic polysaccharide
Paik et al. 2020 Infect Immun 88: e00661-19

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10/17/2026

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Staphylococcus aureus - Wikipedia
https://www.ncbi.nlm.nih.gov/books/NBK441868/