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Preclinical work suggests that probiotics can effectively reduce stress and anxiety and alleviate low mood. However, there is currently limited evidence supporting the effectiveness of probiotics for depression. Probiotics may have a beneficial effect on depressive symptoms when given in addition to antidepressants. Further studies are needed to investigate this and explore possible mechanisms.
According to a meta-analysis of 19 double-blind, randomized, placebo-controlled trials involving 1,901 participants (CRD42018107426), participants treated with probiotics **showed significantly more significant improvement in depressive symptoms than those wh…