ACTRN12615001351505 - Gut Bugs - Fecal Microbiota Transplantation (FMT) & Adiposity / Obesity

Study overview

This is a randomized, double-masked, placebo-controlled trial studying Fecal Microbiota Transplantation (FMT) or placebo in 87 randomized adolescents aged 14 to 18 years with Adiposity / Obesity (body mass index of 30 or more) (1).

Primary outcome measures

BMI standard deviation score at 6 weeks using intention-to-treat analysis (1)

Results (1)

• BMI Standard Deviation Score: There was no significant effect of FMT on the BMI standard deviation score at 6 weeks, with an adjusted mean difference (aMD) of −0.026 (95% CI: −0.074, 0.022).


• Fat Distribution: Reductions in the android-to-gynoid fat ratio were observed in the FMT group compared to the plac…