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Recombinant Interleukin-22 (IL-22) directly targeted intestinal stem cells (ISC), augmenting the growth of both murine and human intestinal organoids, increasing proliferation, and promoting Intestinal Stem Cells (ISCs) expansion
Using ex vivo organoid cultures, we have found that innate lymphoid cells (ILCs), which are potent producers of Interleukin-22 (IL-22) following intestinal injury, significantly increase the growth of murine small intestine (SI) organoids in an IL-22-dependent manner.
Interleukin-22 (IL-22) induces Stat3 phosphorylation in Lgr5+ ISCs, and Stat3 is crucial for both organoid formation and IL-…