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Myeloid Differentiation Primary Response 88 (MYD88) in fibroblasts helps keep the body balanced by boosting the ability of macrophages to fight germs. If MyD88 is removed from fibroblasts, it weakens the germ-fighting ability in the colon of mice, leading to an imbalance in gut bacteria and causing more macrophages that produce Arginase I, which don't respond well to Lipopolysaccharides (LPS). When bone marrow monocytes are exposed to fibroblasts without MyD88, there are more Arginase 1-producing macrophages and fewer macrophages that pr…