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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Clostridium (sensu stricto) (Cluster I) & Colorectal Cancer (CRC)

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Clostridium sensu stricto (Cluster I) has been implicated in colorectal cancer (CRC) development and progression through various mechanisms. This group of bacteria plays a complex role in gut health and CRC, with both potentially harmful and beneficial effects observed.

Harmful Effects

In a study using an animal model of Colorectal Cancer (CRC), higher abundance of Clostridium (sensu stricto) (Cluster I) was observed in rats treated with the carcinogen 1,2-dimethylhydrazine (DMH) compared to control animals. This suggests that certain Clostridium species may contribute to the early stag…

References (Sources)

An Integrative Approach to Characterize the Early Phases of Dimethylhydrazine-Induced Colorectal Carcinogenesis in the Rat
Silva-Reis et al. 2022 Biomedicines 10(2): 409
Clostridium butyricum inhibits epithelial-mesenchymal transition of intestinal carcinogenesis through downregulating METTL3
Zhang et al. 2023h Cancer Sci.114(8): 3114-3127

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7/1/2026

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