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Peripheral neuropathies are a heterogeneous group of diseases. They are characterized by a progressive, ascending loss of nerve function arising from the peripheral regions of the limbs. The phenotypic overlap between different types of hereditary and acquired peripheral neuropathies indicates that similar pathophysiological processes are at play.
Many downstream pathways in peripheral neurons, such as axonal transport, protein degradation, and interactions with Schwann cells, organelle damage, channelopathies, and neuroinflammatory signalling, have already been proposed, each affecting peripheral nerves in a negative way.
[Histone deacetylase 6 (HDAC6)](brain://VNLyqtrJzkmD62FqfkKD1Q/HistoneDeacetyl…