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About half of melanomas contain activating BRAF mutations, with more than 90% of these being BRAF V600E.
Mutations in BRAF outside V600 (non-V600) or BRAF fusions in aggregate occur in approximately 5% of all melanomas
B-RAF V600E in 40-45% of melanoma (cutaneous) pts
BRAF mutations promote melanoma cell proliferation and survival primarily through activation of Mitogen-activated protein kinase 1 (MAPK1) / ERK2
Mitogen-activated protein kinase (MAPK) signal transduction pathway inhibition through the use of agents binding to signal cascade kinases BRAF and MEK has become a key treatment strategy of pati…