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emicizumab, can restore a missing function. Emicizumab is a hetero-IgG in which one arm binds activated coagulation factor IX (FIXa) and the other binds factor X (FX). Emicizumab supplies the bridging function that is normally provided by factor VIII (FVIII), which is missing in individuals with type-A haemophilia.
Sampei et al. 2013 PLoS ONE 8: e57479
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