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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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AMPK/PGC-1alfa/PPARalfa Signal transduction pathway

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These interactions characterize the AMP-activated protein kinase (AMPK)/Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1 alfa (PGC-1 alfa)/Peroxisome proliferator-activated receptor (PPAR) alfa signaling pathway: activation of AMP-activated protein kinase (AMPK) leads to upregulation of Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1 alfa (PGC-1 alfa), and upregulation of Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1 alfa (PGC-1 alfa) coactivates Peroxisome proliferator-activated receptor (PPAR) alfa.

The AMPK/PGC-1alfa/PPARalfa signaling pathway is a critical regulatory axis in cellul…

References (Sources)

Sodium butyrate improves mitochondrial function and kidney tissue injury in diabetic kidney disease via the AMPK/PGC-1α pathway
Yu et al. 2023 Ren Fail. 45(2): 2287129

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7/1/2026

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AMPK/PGC-1alfa/PPARalfa Signal transduction pathway

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