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Naproxen is not specifically approved by the FDA or EMA as a disease-modifying anti-rheumatic drug (DMARD) for rheumatoid arthritis (RA), but it is approved and widely used as a non-steroidal anti-inflammatory drug (NSAID) for symptomatic relief in RA patients. Naproxen is indicated for the relief of the signs and symptoms of rheumatoid arthritis, as well as osteoarthritis and other painful conditions, but it does not modify disease progression—it only reduces inflammation and pain. In clinical practice guidelines and major pharmacological references, naproxen is routinely listed as an option for managing pain and i…