Loading…
Please register to continue your trial period!
meRfi Microbiome provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Phenylacetylglutamine is a microbial metabolite, but more precisely it's a host-microbiome co-metabolite (dual-origin), not a purely bacterial product, since it requires a mandatory host conjugation step to form. Dietary phenylalanine (from egg, meat, dairy, etc.) is transformed by gut bacteria into phenylacetic acid (PAA) - this microbial step is catalyzed by bacterial enzymes phenylpyruvate ferredoxin-oxidoreductase (PPFOR) and phenylpyruvate decarboxylase (PPDC). PAA is then absorbed and conjugated with glutamine in the host liver and kidneys to form phenylacetylglutamine (in rodents, it conjugate…