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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Lactococcus lactis (genetically modified)

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Engineered Lactococcus lactis strains are well-established in biotechnology, with modifications ranging from metabolic pathway engineering to therapeutic protein expression, confirming their status as engineered microbial organisms
Wu et al. 2022 ACS Synth Biol 11(4): 1568-1576
Zhu et al. 2022 Nat Commun 13(1): 7466

Examples are:

Production of Therapeutic Proteins and Vaccination / Vaccines (cytokines, vaccine antigens, [Fusion proteins](brain://SDl99LIJwE21s_wC-Kt6qw/FusionPr…

References (Sources)

A review on Lactococcus lactis: from food to factory
Song et al. 2017 Microb Cell Fact 16(1): 55
Review
Engineered Lactococcus lactis secreting Flt3L and OX40 ligand for in situ vaccination-based cancer immunotherapy
Zhu et al. 2022 Nat Commun 13(1): 7466
Engineered Probiotic Lactococcus lactis for Lycopene Production against ROS Stress in Intestinal Epithelial Cells
Wu et al. 2022 ACS Synth Biol 11(4): 1568-1576
Engineering Lactococcus lactis for Increased Vitamin K2 Production
Bøe et al. 2020 Front Bioeng Biotechnol 8: 191
Lactococcus lactis engineered to deliver hCAP18 cDNA alleviates DNBS-induced colitis in C57BL/6 mice by promoting IL17A and IL10 cytokine expression
Noguès et al. 2022 Sci Rep 12: 15641
Recent advances of engineered probiotics for therapeutic applications
Zhang et al. 2025 Biodes Res 7(3): 100039
Review
Targeting IL-6 by engineered Lactococcus lactis via surface-displayed affibody
Zahirović & Berlec 2022 Microb Cell Fact 21: 143

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7/1/2026

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