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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Microprotein

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Contents

Small Open Reading Frames (ORFs) (smORFs, alternatively sORFs; length ≤50 amino acids) encode microproteins (also called small proteins)
Durrant & Bhatt 2021 Cell Host & Microbe 29: 121-131

These play an essential role in microbes (e.g., a potential role in Cell-To-Cell Communication / Cell Signaling)
Hanada et al. 2013 Proceedings of the National Academy of Sciences of the United States of America, 110(6): 2395-2400
Storz et al. 2014 Annual review of biochemistry, 83: 753-777
Makarewich et al. 2018 Cell reports, 23(13): 3701-3709

The smORFs (small [Open Reading Frames (ORFs)](brain://PKlGKb1AmEKyZsfmhQJyBA/OpenReadingFrames…

References (Sources)

‘Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes
Weaver et al. 2019 mBio, 10(2). doi: 10.1128/mBio.02819-18
‘Small bacterial and phagic proteins: an updated view on a rapidly moving field
Duval & Cossart 2017 Curr Opin Microbiol 39: 81-88
Review
Function is what counts: how microbial community complexity affects species, proteome and pathway coverage in metaproteomics
Lohmann et al. 2020 Expert review of proteomics, 17(2): 163-173
MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β Oxidation’
Makarewich et al. 2018 Cell reports, 23(13): 3701-3709
Small open reading frames associated with morphogenesis are hidden in plant genomes
Hanada et al. 2013 Proceedings of the National Academy of Sciences of the United States of America, 110(6): 2395-2400
Small proteins: untapped area of potential biological importance
Su et al. 2013 Frontiers in genetics, 4: 286
Unraveling the hidden universe of small proteins in bacterial genomes
Miravet-Verde et al. 2019 Molecular systems biology, 15(2): e8290

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7/1/2026

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Microprotein - Wikipedia