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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Cancer / Tumors & Methionine gamma-lyase

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Normal cells are less affected, making Methionine gamma-lyase a selectively toxic agent for tumor cells
Abo Qoura et al. 2024 Biochim Biophys Acta Rev Cancer 1879(4): 189122
Ardjmand et al. 2024 Anticancer Research March 44(3): 929-933
Morinaga et al. 2024 Anticancer Res 44(3): 921-928
Morinaga et al. 2024 Anticancer Res 44(6): 2359-2367

The vulnerability of many cancer cells is known as methionine addiction. This addiction, called the Hoffman effect, refers to the much greater reliance of cancer cells on methionine for growth and survival, compared to normal cells
Sharma et al. 2014 Biomed Res Int 2014: 506287
Abo Qoura et al. 2024 Biochim Biophys Acta R…

References (Sources)

A review on L-methioninase in cancer therapy: Precision targeting, advancements and diverse applications for a promising future
Javia et al. 2024 Int J Biol Macromol 265(Pt 2): 130997
Review
DNA-Binding Agent Trabectedin Combined With Recombinant Methioninase Is Synergistic to Decrease Fibrosarcoma Cell Viability and Induce Nuclear Fragmentation But Not Synergistic on Normal Fibroblasts
Morinaga et al. 2024 Anticancer Res 44(6): 2359-2367
Expression of PD-L1 Is Increased by Methionine Restriction Using Recombinant Methioninase in Human Colorectal Cancer Cells
Mizuta et al. 2024 Cancer Genomics Proteomics 21(4): 395-398
Extensive Synergy Between Recombinant Methioninase and Eribulin Against Fibrosarcoma Cells But Not Normal Fibroblasts
Morinaga et al. 2024 Anticancer Res 44(3): 921-928
Isolation and characterization of Trichoderma harzianum L-methioninase with promising a powerful anticancer
Ashkan et al. 2023 Saudi J Biol Sci 30(12): 103870
L-methionase: a therapeutic enzyme to treat malignancies
Sharma et al. 2014 Biomed Res Int 2014: 506287
Review
The potential of methioninase for cancer treatment
Abo Qoura et al. 2024 Biochim Biophys Acta Rev Cancer 1879(4): 189122
Review

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