TcdE

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TcdE is a small (166 amino acid) protein encoded by the tcdE* gene,* located within the pathogenicity locus (PaLoc) of Clostridioides difficile (formerly Clostridium difficile*),* positioned between the genes for its two major toxins, tcda gene and tcdb gene (1)

Clostridium difficile toxins: mechanism of action and role in disease
Voth & Ballard 2005 Clin Microbiol Rev 18(2): 247-63
Review
Evidence for holin function of tcdE gene in the pathogenicity of Clostridium difficile
Tan et al. 2001 J Med Microbiol 50(7): 613-619
Observations on the Role of TcdE Isoforms in Clostridium difficile Toxin Secretion
Govind et al. 2015 J Bacteriol 197(15): 2600-9
Regulation of Clostridioides difficile toxin production
Majumdar & Govind 2022 Curr Opin Microbiol 65: 95-100
Secretion of Clostridium difficile toxins A and B requires the holin-like protein TcdE
Govind & Dupuy 2012 PLoS Pathog 8(6): e1002727

11/5/2026