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Progranulin (PGRN, encoded by the grn gene non-mut.) plays a crucial role in the development, survival, function, and maintenance of neurons and microglia in the mammalian brain.
Rhinn et al. 2022 Trends in Pharmacological Sciences 43(8): 641
Progranulin regulates lysosomal biogenesis, inflammation, repair, stress response, and aging.
Rhinn et al. 2022 Trends in Pharmacological Sciences 43(8): 641
Increasing and/or restoring PGRN levels is an attractive therapeutic strategy and is being studied for neurodegenerative diseases through multiple mechanisms of action.
Rhinn et al. 2022 Trends in Pharmacological Sciences 43(8): 641…