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Extrathymic differentiation of Treg cells impacts commensal microbiota composition and serves a distinct, essential function in restraint of allergic type inflammation at mucosal interfaces
In the colon and small intestine, CD4+ CD25+ FOXP3 high Treg (peripherally induced) exhibit distinct phenotypic and likely functional characteristics. In the small intestine, Tregs are induced as a response to Food antigens, whereas in the [colon](brain://QPZxhOYHq0CebAhpYkseNw/Dis…