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Anti-PD-1 resistance is a significant challenge in cancer immunotherapy, limiting the effectiveness of these treatments for many patients.
Mechanisms of resistance come from
Tumor Microenvironment Factors and tumor cell adaptations
Myeloid-derived suppressor cells (MDSCs) play a crucial role in anti-PD-1 resistance. They express CD274 (Programmed death-ligand 1 (PD-L1)), which interacts with CD279 (Programmed cell death protein 1 (PD-1) on T cells, inhibiting cytotoxic T lymphocyt…